Journal: Pharmaceuticals

Article Title: Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

doi: 10.3390/ph18020209

Figure Lengend Snippet: Mechanisms of flavonoid and polyphenol compounds in the antibacterial and anti-inflammatory treatment of acne.

Article Snippet: Resveratrol , Nanoemulsion gel containing adapalene and 5 mg of resveratrol (F1), applied once daily. Nanoemulsion gel containing adapalene and 10 mg of resveratrol (F2), applied once daily. , Surfactant-based nanocarrier , The prepared nanoemulsion gel formulation containing adapalene and resveratrol showed better efficacy in treating acne pustules compared to the marketed formulation. The treatment time was significantly shorter for the prepared formulations. , [ ] .

Techniques: Activity Assay, Bacteria, Activation Assay, Phospho-proteomics, Expressing

Journal: Pharmaceuticals

Article Title: Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

doi: 10.3390/ph18020209

Figure Lengend Snippet: Efficacy of flavonoid and polyphenol nanoparticle formulations in acne treatment.

Article Snippet: Resveratrol , Nanoemulsion gel containing adapalene and 5 mg of resveratrol (F1), applied once daily. Nanoemulsion gel containing adapalene and 10 mg of resveratrol (F2), applied once daily. , Surfactant-based nanocarrier , The prepared nanoemulsion gel formulation containing adapalene and resveratrol showed better efficacy in treating acne pustules compared to the marketed formulation. The treatment time was significantly shorter for the prepared formulations. , [ ] .

Techniques: Polymer, Activity Assay, Formulation, Liposomes, Antioxidant Activity Assay, Concentration Assay

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Adapalene chemical structure.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques:

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Normalized UVA absorption band in the different solvents. ( acetonitrile, ethyl acetate, 1,4-dioxane, ethanol, hexane, methanol, dichloromethane, DMF, THF). Inset: Normalized UV-vis absorption spectra of adapalene in acetonitrile, ethanol and hexane.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques:

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Absorption (λ A , nm) and fluorescence (λ F , nm) maxima, Stokes shift (Δν, cm −1 ) of adapalene in solvents of different polarity (dielectric constant, є, refractive index, n, and E T (30) parameter).

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques: Fluorescence, Refractive Index

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Absorption of adapalene alone (10 μM, gray), DNA (50 μM in bp, dotted green line) or adapalene in the presence of DNA (full green line) in PBS at pH 7.4. Inset: adapalene alone (10 μM, gray), HSA alone (2 μM, dotted blue line), of adapalene in the presence of HSA (full blue line).

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques:

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Normalized fluorescence spectra of adapalene in different solvents.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques: Fluorescence

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: (A) Position of the emission maxima in wavenumber of adapalene versus the polarity E T (30) in different solvents or in dioxane:ethanol mixtures (inset). (B) Lippert-Mataga plot for adapalene in different solvents or in dioxane:ethanol mixtures (inset).

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques:

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Fluorescence emission (λ exc = 315 nm) of a solution containing adapalene (10 μM) and HSA (12 μM) in PBS at pH 7.4, adapalene alone in PBS (gray dotted line). Inset emission changes as a function of the protein concentration.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques: Fluorescence, Protein Concentration

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Fluorescence emission (λ exc = 315 nm) of adapalene (10 μM) alone in PBS at pH 7.4 (black) and in the presence of duplex salmon sperm DNA (from 25 to 400 μM in bp). Inset: Stern-Volmer plot for the quenching of adapalene fluorescence in PBS (blue), with 10 μM bp (orange) or 100 μM bp (grey) of DNA.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques: Fluorescence

Journal: Frontiers in Chemistry

Article Title: Environmentally sensitive fluorescence of the topical retinoid adapalene

doi: 10.3389/fchem.2024.1438751

Figure Lengend Snippet: Emission spectra of adapalene (10 μM) varying CTAB concentration (from 0.05 to 4 mM) in PBS and adapalene alone in PBS (gray dotted line), λ exc = 315 nm. Inset: Representation of the changes of 390 nm emission vs. the logarithm of CTAB concentration.

Article Snippet: Adapalene was purchased from BIOSYNTH Carbosynth and was used without further purification.

Techniques: Concentration Assay